| RF | EOS R System mirrorless cameras | Specifically designed for EOS R System, offers native compatibility |
| RF-S | EOS R System mirrorless cameras | Specifically designed for APS-C sensor size within EOS R System, offers native compatibility |
| EF | Canon EOS DSLR cameras | Can be used on EOS R System cameras with EF-EOS R Mount Adapter |
| TS-E (tilt-shift) | Canon EOS DSLR cameras | Can be used on EOS R System cameras with EF-EOS R Mount Adapter |
| MP-E (macro) | Canon EOS DSLR cameras | Can be used on EOS R System cameras with EF-EOS R Mount Adapter |
| EF-S | APS-C DSLR cameras | Cannot be used with full-frame DSLRs, but compatible with EOS R System cameras via adapter |
| EF-M | EOS M mirrorless cameras | Designed exclusively for EOS M cameras, not compatible with other camera types |